| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R1 is H, CH3, or C2H5; R2 is H, lower alkyl, lower alkoxy, halogen, or nitro; R3 is H, or lower alkyl; k is integer of 0-3; m is 0 or 1; X and Y are H, or CH3; A is group shown by the formula -N(R4)(R5) (R4 and R5 are lower alkyl, or form ring through O or without O, or shown by the formula II (n is 2 or 3; R6 is lower alkyl)] or its pharmaceutically accetable acid addition salt. EXAMPLE:N-(2-Diethylaminoethyl)-3-methylflavone-8-carboxamide. USE:A remedy for disorders of urinary tract. PREPARATION:A compound shown by the formula III [R7 is OH, halogen, -OR8, -O-COOR9 (R8 and R9 are lower alkyl)] is reacted with a compound shown by the formula IV in the presence of a condensation agent (e.g., N,N-dicyclohexylcarbodiimide) in an inert organic solvent at room temperature, to give a compound shown by the formula I . |
