Cyclic lipopeptides having antibiotic activity.

摘要

The present invention is directed to water-soluble derivatives of antibiotic lipopeptides having the formula. <CHEM> wherein R is H or OH and R min is a phosphono, sulfo or acyl radical possessing a charged group at neutral pH. The derivatives are esters but having a charged group, have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.