| 发明名称 |
Methods for screening monoclonal antibodies for therapeutic use |
| 摘要 |
The present invention provides a method for selecting from among many monoclonal antibodies capable of binding to a surface antigen on a tumor cell, the antibody which also can internalize into the cell and exert an appropriate molecular effect on the level of gene regulation in the tumor cell. Such antibodies can most effectively be employed to damage the tumor cell.
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| 申请公布号 |
US5296348(A) |
申请公布日期 |
1994.03.22 |
| 申请号 |
US19890352258 |
申请日期 |
1989.05.16 |
| 申请人 |
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY |
发明人 |
RAKOWICZ-SZULCZYNSKA, EWA;KOPROWSKI, HILARY |
| 分类号 |
A61K38/00;C07K16/30;G01N33/50;G01N33/574;(IPC1-7):C12Q1/68;G01N33/566;C07H21/02;C12N15/00 |
主分类号 |
A61K38/00 |
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