PEPTIDES CONTAINING RESPECTIVE AMINO ACID SEQUENCES SELECTED FROM AMONG THOSE OF LIPOPROTEIN(a) AND APOLIPOPROTEIN(a), ANTIBODIES RESPECTIVELY RECOGNIZING THESE AMINO ACID SEQUENCES, AND METHOD OF ASSAYING WITH THESE ANTIBODIES.

摘要

Amino acid sequences which have a specificity as a lipoprotein(a) and are lowly homologous with LDL and plasminogen are selected from among the amino acid sequences of the lipoprotein(a) to obtain antibodies against the lipoprotein(a) which specifically recognize these amino acid sequences. At least one of these antibodies is used in the immunoassay of the lipoprotein(a). Amino acid sequences which have a specificity as an apolipoprotein(a) and do not have antigenicities as the lipoprotein(a) and plasminogen are selected from among the amino acid sequences of the apolipoprotein(a) to obtain antibodies against the apolipoprotein(a) which specifically recognize these amino acid sequences. At least one of these antibodies is used in the immunoassay of the apolipoprotein(a). The invention serves to prepare antibodies against lipoprotein(a) and apolipoprotein(a) more readily than the conventional methods and to conduct the immunoassay of the lipoprotein(a) and apolipoprotein(a) accurately by using the antibodies.