Iodo vitamin D3compounds and method for preparing same

摘要

Biologically active 1 alpha -hydroxy-22-iodinated vitamin D3 compounds and a process for the preparation of 1 alpha -hydroxy-22-iodinated vitamin D3 compounds are disclosed. The 22-iodo-vitamin D3 compounds show relatively high binding affinity for the vitamin D receptor demonstrating their potential for high in vivo biological activity. Further, these compounds induce relatively high differentiation of malignant cells. Also, these 22-iodo compounds show high in vivo calcium transport activity with little or no bone calcium mobilization activity. These compounds thus show promise in the treatment of osteoporosis.