LIQUID POLYMER DELIVERY SYSTEM

摘要

The invention provides a liquid drug delivery system made of a low molecular weight, biodegradable, water-insoluble, liquid polymer or copolymer combined with an active agent, and optional additives such as a modifying agent. The polymer or copolymer has a sufficiently low molecular weight to maintain the polymer composition as a liquid before and after introduction into the body of an animal. The liquid compositions are administered to an implant site in liquid form and remain as a liquid in situ to provide controlled release of the active agent. Also provided are methods of forming the liquid delivery system and a liquid polymer matrix in vivo, and of using the formulations for release of an active agent in vivo for treatment in an animal including a human patient.