发明名称 |
MODIFIED GAMMA DELTA CELLS AND USES THEREOF |
摘要 |
The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta Τ cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR). |
申请公布号 |
WO2016166544(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
WO2016GB51050 |
申请日期 |
2016.04.14 |
申请人 |
TC BIOPHARM LTD |
发明人 |
LEEK, Michael David;HANNIGAN, Adele;PATAKAS, Agapitos;PARUZINA, Daria |
分类号 |
C12N5/0783;A61K35/17;C07K14/725 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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