A method of detecting in a sample CTL specific for a particular virus, e.g. HIV, comprises contacting the sample with a support carrying immobilized antibodies to a surface antigen on T cells; separating the support and attached materials; contacting the separated support with target cells matched to the HLA type of the source of the sample and with HLA matched peptide epitope of the virus that interacts with the CTL of interest; and monitoring lysis of the target cells.
申请公布号
WO9200524(A1)
申请公布日期
1992.01.09
申请号
WO1991GB00963
申请日期
1991.06.14
申请人
MEDICAL RESEARCH COUNCIL;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVER
发明人
MCMICHAEL, ANDREW, JAMES;NIXON, DOUGLAS, FRASER;GOTCH, FRANCES, MARGARET