发明名称 |
COMPOSITIONS AND METHODS FOR BLOOD-BRAIN BARRIER DELIVERY OF IGG-DECOY RECEPTOR FUSION PROTEINS |
摘要 |
Provided herein are compositions and related methods for delivering an IgG-decoy receptor to the CNS. The methods include systemic administration of a bifunctional decoy receptor-BBB receptor antibody fusion antibody comprising a receptor extracellular domain (ECD) covalently linked to an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor). In some embodiments, the compositions described herein are administered to treat a subject suffering from a CNS condition. |
申请公布号 |
US2017066832(A1) |
申请公布日期 |
2017.03.09 |
申请号 |
US201615357894 |
申请日期 |
2016.11.21 |
申请人 |
ArmaGen Technologies, Inc. |
发明人 |
PARDRIDGE William;BOADO Ruben J. |
分类号 |
C07K16/28;C07K14/705 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Calabasas CA US |