Anti-fXI antibodies and methods of use

摘要

Disclosed herein are monoclonal antibodies specific for factor XI (fXI) that prevent activation of fXI by factor XIIa (fXIIa). The monoclonal antibodies are universal fXI antibodies, capable of binding all mammalian species tested. The anti-fXI monoclonal antibodies prolong clotting time in mammalian plasmas. Moreover, administration of the fXI monoclonal antibodies disclosed herein results in inhibition of thrombosis without altering hemostasis in animal models of thrombosis. Thus, provided herein are monoclonal antibodies specific for fXI that block activation of fXI by fXIIa, compositions and immunoconjugates comprising such antibodies and their methods of use.

主权项

1. An isolated monoclonal antibody, or antigen-binding fragment thereof, specific for coagulation factor XI (DU), comprising a variable light (VL) chain and a variable heavy (VH) chain, wherein:
the VL chain comprises a complementarity determining region 1 (CDR1), a CDR2 and a CDR3 sequence of SEQ ID NO: 1; and the VH chain comprises a CDR1, a CDR2 and a CDR3 sequence of SEQ ID NO: 3.