发明名称 |
Cytotoxicity-inducing therapeutic agent |
摘要 |
A novel multispecific antigen-binding molecule, which comprises a domain containing an antibody variable region having an activity of binding to glypican 3 and a domain containing an antibody variable region having an activity to bind to a T cell receptor complex and retains excellent cytotoxic activity and high safety, was found. The molecule according to the present invention exhibits potent cytotoxic activity on cells and tissues expressing glypican 3 and, therefore, enables the production of new pharmaceutical compositions for treating or preventing various kinds of cancers. |
申请公布号 |
AU2015322543(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
AU20150322543 |
申请日期 |
2015.09.25 |
申请人 |
Chugai Seiyaku Kabushiki Kaisha |
发明人 |
Nezu, Junichi;Narita, Atsushi;Ishiguro, Takahiro;Sakurai, Mika;Shiraiwa, Hirotake;Hironiwa, Naoka;Igawa, Tomoyuki;Kawai, Yumiko |
分类号 |
C12N15/09;A61K39/395;A61P35/00;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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