Device for the Separation of Particles Using a Bulk Acoustic Wave Field

摘要

The disclosure describes a prism containing a microfluidic channel. By coupling bulk acoustic wave generators to opposing sides of the prism, a standing bulk acoustic wave field can be excited in the prism and in the microfluidic channel. Because the microfluidic channel is titled with respect to the nodes of the bulk acoustic wave field, the prism microfluidic channel device can be used to separate microparticles and biological cells by size, compressibility, density, shape, or mass distribution. This technology enables high throughput cell sorting for biotechnology applications such as cancer cell detection.

主权项

1. A particle separation device comprising:
a prism; a microchannel disposed within an interior portion of the prism; a first bulk acoustic wave generator acoustically coupled to a first side of the prism; a second bulk acoustic wave generator acoustically coupled to a second side of the prism,
wherein the first side is opposite the second sidewherein the bulk acoustic wave generators create at least one standing wave within the microchannel,wherein the at least one standing wave is not parallel to a side of the microchannel.