发明名称 |
METHODS FOR THE DESIGN OF MECHANISM-BASED SIRTUIN ACTIVATING COMPOUNDS |
摘要 |
The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate. |
申请公布号 |
WO2017048836(A1) |
申请公布日期 |
2017.03.23 |
申请号 |
WO2016US51726 |
申请日期 |
2016.09.14 |
申请人 |
PMC ADVANCED TECHNOLOGY LLC |
发明人 |
CHAKRABARTI, Raj;UPADHYAY, Alok;MUNSHI, Sudipto;RAMASWAMY, Suyambu, Kesava Vijayan;GUAN, Xiangying |
分类号 |
G01N33/50;C12N9/10;C12Q1/00;C12Q1/48;G01N33/573;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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地址 |
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