Compositions for treating obesity and insulin resistance disorders

摘要

Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

主权项

1. A method for treating an insulin resistance disorder in a subject in need thereof, comprising administering to the subject nicotinamide riboside or a nicotinamide riboside analog represented by formula A: wherein R represents independently for each occurrence H, acetyl, benzoyl, acyl, phosphate, sulfate, (alkyoxy)methyl, triarylmethyl, (trialkyl)silyl, (dialkyl)(aryl)silyl, (alkyl)(diaryl)silyl, or (triaryl)silyl; and X represents 0 or S, at a concentration of 1 nM to 10 μM, wherein the subject is a human subject.