发明名称 |
PHOTO-CONTROLLED REMOVAL OF TARGETS IN VITRO AND IN VIVO |
摘要 |
This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule, to one that is hydrophobic, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory. |
申请公布号 |
SG11201610052T(A) |
申请公布日期 |
2017.02.27 |
申请号 |
SGT11201610052 |
申请日期 |
2015.08.07 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KOBAYASHI, HISATAKA;CHOYKE, PETER;SCHNERMANN, MARTIN, JOHN |
分类号 |
A61K41/00;A61K49/00 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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