TM-ENHANCED BLOCKING OLIGONUCLEOTIDES AND BAITS FOR IMPROVED TARGET ENRICHMENT AND REDUCED OFF-TARGET SELECTION
摘要
The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.
申请公布号
SG10201610861X(A)
申请公布日期
2017.02.27
申请号
SGX10201610861
申请日期
2013.07.03
申请人
INTEGRATED DNA TECHNOLOGIES, INC.;FOUNDATION MEDICINE, INC.
发明人
BEHLKE, MARK AARON;HAVENS, JOHN ROBERT;ROSE, SCOTT DANIEL;JAROSZ, MIRNA;ZWIRKO, ZACHARY;LIPSON, DORON;JUHN, FRANK SOO