发明名称 |
ENGINEERED RABBIT ANTIBODY VARIABLE DOMAINS AND USES THEREOF |
摘要 |
The present invention relates to methods for screening and producing polypeptides that immunospecifically bind to an antigen, which : polypeptides comprise binding domains that are derived from rabbit immunoglobulin. Using rabbit antibody heavy-chain or light-chain scaffolds, the methods of the invention allow identification of novel CDR loops and framework regions that confer enhanced stability and/or affinity to isolated immunoglobulin variable domains, in particular, relative to those derived from rodent antibodies. The enhanced stability and/or affinity of the variable domains of the invention permit their use in the production research tools or therapeutic immunospecific polypeptides, including single domain immunospecific polypeptides, i.e., comprising one of a VH or VL domain. |
申请公布号 |
CA2685213(C) |
申请公布日期 |
2017.02.21 |
申请号 |
CA20082685213 |
申请日期 |
2008.04.30 |
申请人 |
TECHNOPHAGE, INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA;CASTANHEIRA AIRES DA SILVA, FREDERICO NUNO |
发明人 |
BRAZ GONCALVES, JOAO MANUEL;CASTANHEIRA AIRES DA SILVA, FREDERICO NUNO |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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