Use of cannabinoids in the treatment of epilepsy

摘要

Cannabidiolic acid (CBDA) for use in the treatment of epilepsy, preferably where the epilepsy is a generalised epilepsy characterised by tonic-clonic seizures. Preferably the CBDA is in the form of a highly purified extract of cannabis such that the CBDA is present at greater than 98% of the total extract (w/w) and comprises less than 1% (w/w) tetrahydrocannabinol (THC) or tetrahydrocannabinol acid (THCA). The CBD may be synthetically produced. The CBDA may be used with cannabidiol (CBD) preferably where the CBDA:CBD ratio is in the range from 9:1 to 1:9 (CBDA:CBD). Preferably the CBD is used at a dose of from 1mg-100mg.