| 发明名称 | Multiple-layer immune barrier for donor cells | ||
| 摘要 | A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described. | ||
| 申请公布号 | US9566366(B2) | 申请公布日期 | 2017.02.14 |
| 申请号 | US201615233119 | 申请日期 | 2016.08.10 |
| 申请人 | Beta-O2 Technologies Ltd. | 发明人 | Barkai Uriel;Rotem Avi;Bremer Yehezkel;Neufeld Tova |
| 分类号 | A61K9/00;A61J3/06;A61P1/18;A61K35/12;A61K35/39;A61L27/00;A61L27/34;A61L27/36;A61L27/56;A61L27/50;C12N5/00;A01N1/02;C12N5/071 | 主分类号 | A61K9/00 |
| 代理机构 | Greenberg Traurig, LLP | 代理人 | Greenberg Traurig, LLP |
| 主权项 | 1. A method for encapsulating a plurality of donor cells in a housing comprising a cover, comprising: encapsulating the plurality of donor cells in a first alginate structure having a guluronic acid concentration of between 64% and 74%; disposing the first alginate structure in the housing; surrounding a second alginate structure having a mannuronic acid concentration of between 52% and 60% with a selectively-permeable membrane to form a membrane-alginate structure; coupling the membrane-alginate structure to the cover; and covering the first alginate structure disposed in the housing with the cover coupled to the membrane-alginate structure. | ||
| 地址 | Petach-Tikva IL | ||