Preparation for use of aspartate and vitamin B12 or biotin for regulating ketone bodies

摘要

It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalised. Thus, it is an object of the invention to provide an enteral nutritional or a pharmaceutical composition for the treatment and/or prevention of disturbed ketone and lactate metabolism, i.e. elevated concentrations of ketone bodies, lactate and/or other organic acids and/or insufficient pH homeostasis, especially elevated concentrations of ketone bodies and/or lactate, in a mammal's blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, preferably in relative absence of glutamate equivalents.

主权项

1. An enteral nutritional composition comprising a protein fraction and a carbohydrate fraction providing 15-22 en % and 25-50 en %, respectively, wherein the protein fraction comprises at least 10.8 wt % of aspartate equivalents, based on the total weight of the protein fraction, wherein the protein fraction comprises a first aspartate-rich source selected from a protein, a protein concentrate, isolate or hydrolysate and free aspartate equivalents, and a second aspartate-rich source different form the first source, and wherein the composition further comprises at least one of vitamin B12 and biotin.