发明名称 |
METHOD FOR PRODUCING BETA-HEMATIN CRYSTALS INCLUDING A HEATING STEP |
摘要 |
This invention provides a method of preparing a ²-hematin crystal comprising a step of heating, the ²-hematin crystal obtained by such method, and a vaccine adjuvant composition containing the ²-hematin crystal. The ²-hematin crystal has a needle-like morphology, it has an average particle size of 0.6 to 1.2 µm, and it exhibits main peaks characteristics for angles of diffraction (2¸) of 7.4°, 12.2°, 21.6°, and 24.1° in an X-ray diffraction pattern obtained by powder X-ray diffractometry with Cu-K± rays (with each peak including a plus-minus 0.2° diffraction angle). |
申请公布号 |
EP3006446(A4) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20140808301 |
申请日期 |
2014.06.04 |
申请人 |
OSAKA UNIVERSITY;NIPPON ZENYAKU KOGYO CO., LTD. |
发明人 |
AKIRA, SHIZUO;ISHII, KEN;COBAN, CEVAYIR;IGARI, YOSHIKATSU;KANO, YASUMASA;OTSUKI, AKINA |
分类号 |
C07D487/22;A61K39/39;A61P37/04 |
主分类号 |
C07D487/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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