发明名称 |
PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene, and methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and methods of treating subjects having Nonalcoholic Fatty Liver Disease (NAFLD) and/or a PNPLA3-associated disorder. |
申请公布号 |
WO2016130806(A3) |
申请公布日期 |
2016.10.20 |
申请号 |
WO2016US17550 |
申请日期 |
2016.02.11 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
FITZGERALD, Kevin;HINKLE, Gregory |
分类号 |
C12N15/113;A61K31/713 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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