发明名称 |
ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell. |
申请公布号 |
EP3078753(A1) |
申请公布日期 |
2016.10.12 |
申请号 |
EP20160167704 |
申请日期 |
2011.05.09 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
HAURWITZ, RACHEL E.;DOUDNA, JENNIFER A.;WIEDENHEFT, BLAKE;JINEK, MARTIN |
分类号 |
C12Q1/68;C12N9/22;C12N15/55;C12Q1/34;G01N33/573 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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