EFFICIENT CHILLER FOR A SUPERCRITICAL FLUID CHROMATOGRAPHY PUMP

摘要

Methods and systems for pumping compressible fluids in high pressure applications such as high-pressure liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) applications are disclosed. An improved cooling device for a pump head for use in a supercritical fluid chromatography (SFC) system is described. A system for chilling a pumping system, includes a Peltier cooling element in thermal contact with a pump head, wherein the cooling element chills the pump head and a mobile phase fluid flowstream prior to the mobile phase fluid entering the pump; a fluid-cooled heat exchanger, attached to the Peltier cooling element, which removes heat from the cooling element using a circulating fluid; and a second heat exchanger which cools the circulating fluid.

主权项

1. A supercritical fluid chromatography (SFC) system, comprising:
a pumping system configured to drive supercritical carbon dioxide as a mobile phase through a stationary phase for separating compounds of a sample introduced into the mobile phase downstream from the pumping system; and a mobile phase supply configured to supply carbon dioxide gas to the pumping system.