The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.
申请公布号
EP2934597(A4)
申请公布日期
2016.07.20
申请号
EP20130863999
申请日期
2013.12.19
申请人
MEDIMMUNE, LLC
发明人
HUNTER, ALAN;LINKE, THOMAS;PABST, TIM;WENDELER, MICHAELA;WANG, XIANGYANG;TOHMPSON, CHRIS;XI, GUOLING;FULTON, ANDREW