| 主权项 |
1. A process for large scale separation of molecules comprising the steps:
providing magnetic particles (P) having an affinity to said molecules to be separated, mixing said magnetic particles (P) with a solution containing said molecules, bringing said mixture in contact with a magnetic separation device comprising a flow channel and at least one magnetic element, removing said at least one magnetic element and collecting the magnetic particles (P) carrying said molecules, separating said molecules from said magnetic s particles (P), obtaining a concentrated fraction of said molecules, and recirculating the magnetic particles (P),wherein the magnetic particles (P) comprise particles (Pp) having an exterior surface, pores and a connected interior surface defined by said pores, said particles (Pp) comprising at least one polymer, functional groups on said exterior and interior surfaces and magnetic particles (Mp) covalently bound to the interior and exterior surface of said particles (Pp), wherein the smallest diameter of at least 95 wt % of all magnetic particles (Mp) is larger than the average diameter of at least 95% of the pores of the particles (Pp). |
