发明名称 |
MONITORING DIFFUSE LARGE B-CELL LYMPHOMA FROM PERIPHERAL BLOOD SAMPLES |
摘要 |
The invention is directed to sequencing-based methods for monitoring a minimal residual disease of a diffuse large B cell lymphoma (DLBCL) by one or more clonotypes correlated with the disorder. In some embodiments, such methods comprise the following steps: (a) obtaining a sample of peripheral blood from the patient; (b) amplifying molecules of nucleic acid from the sample, the molecules of nucleic acid comprising recombined DNA sequences from immunoglobulin genes; (c) sequencing the amplified molecules of nucleic acid to form a clonotype profile; and (d) determining from the clonotype profile a presence, absence and/or level of one or more patient-specific clonotypes correlated with the DLBCL and phylogenic clonotypes thereof. |
申请公布号 |
EP2909342(A4) |
申请公布日期 |
2016.06.22 |
申请号 |
EP20130846484 |
申请日期 |
2013.10.17 |
申请人 |
ADAPTIVE BIOTECHNOLOGIES CORPORATION |
发明人 |
CARLTON, VICTORIA;FAHAM, MALEK |
分类号 |
C12Q1/68;C40B20/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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