| 发明名称 |
ULTRA-PURE AGONISTS OF GUANYLATE CYCLASE C, METHOD OF MAKING AND USING SAME |
| 摘要 |
The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step. |
| 申请公布号 |
US2016145307(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201414896019 |
申请日期 |
2014.06.05 |
| 申请人 |
SYNERGY PHARMACEUTICALS, INC. |
发明人 |
SHAILUBHAI Kunwar;COMISKEY Stephen;FENG Rong;BAI Juncai;ZHANG Ruoping;JIA Jun;ZHOU Junfeng;ZHAO Qiao;ZHANG Guoqing |
| 分类号 |
C07K7/08;B01D15/42 |
主分类号 |
C07K7/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A purified peptide comprising the GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1, 9, and 104, wherein the purified peptide has the following characteristics:
a) has a bulk density of not greater than 0.1 g/mL; b) contains less than 50 ppm acetamide; and d) less than 0.3% alpha-Asp-9-plenacanatide (RRT 1.33). |
| 地址 |
New York NY US |
