| 发明名称 |
EFFECTOR-DEFICIENT ANTI-CD32A ANTIBODIES |
| 摘要 |
Effector-deficient anti-CD32a monoclonal antibodies are encompassed, as are method and uses for treating CD32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders. |
| 申请公布号 |
US2016145336(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201414555556 |
申请日期 |
2014.11.26 |
| 申请人 |
Adventist Health System/Sunbelt Inc. |
发明人 |
Francis John;Amirkhosravi Ali;Meyer Todd;Robles-Carrillo Liza |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for blocking CD32a and/or preventing CD32a activation in a human subject comprising: administering a therapeutically effective amount of an effector-deficient anti-CD32a monoclonal antibody to a human subject, wherein the antibody comprises at least a portion of an Fc region and is effector-deficient, thereby blocking CD32a and/or preventing CD32a activation. |
| 地址 |
Altamonte Springs FL US |
