| 发明名称 |
STABLE CRYSTAL FORM OF TIPIRACIL HYDROCHLORIDE AND CRYSTALLIZATION METHOD FOR THE SAME |
| 摘要 |
An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride. The present invention provides a crystal of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride exhibiting characteristic peaks at angles of 11.6°, 17.2°, 17.8°, 23.3°, 27.1°, and 29.3° as a diffraction angle (2θ±0.1°) in powder X-ray diffraction. |
| 申请公布号 |
US2016145241(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201414896748 |
申请日期 |
2014.06.17 |
| 申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
KAZUNO Hideki;MUTSUMI Tomonobu |
| 分类号 |
C07D403/06 |
主分类号 |
C07D403/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A crystal of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride exhibiting peaks at two or more angles selected from the group consisting of 11.6°, 17.2°, 17.8°, 23.3°, 27.1°, and 29.3° as a diffraction angle (2θ±0.1°) in powder X-ray diffraction. |
| 地址 |
Tokyo JP |
