| 发明名称 |
SIGNATURE OF TL1A (TNFSF15) SIGNALING PATHWAY |
| 摘要 |
The present invention relates to the finding that TL1A enhances differentiation of TH17 cells, and enhance IL17 secretion from TH17 cells. In one embodiment, the present invention provides a method of treating an inflammatory disease comprising determining the presence of a TL1A signaling profile, and treating the disease by administering a composition comprising a therapeutically effective dosage of one or more inhibitors of TL1A or TH17 cell differentiation. In another embodiment, the disease is characterized by TH17 differentiation. |
| 申请公布号 |
EP3022295(A1) |
申请公布日期 |
2016.05.25 |
| 申请号 |
EP20140826746 |
申请日期 |
2014.07.18 |
| 申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
MICHELSEN, KATHRIN S.;TARGAN, STEPHAN R. |
| 分类号 |
C12N5/0783;A61K45/06;C07K16/24;C07K16/28 |
主分类号 |
C12N5/0783 |
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