Amino Acid Sequence Presenting Fusion Polypeptide And Its Use

摘要

Herein is reported a fusion polypeptide according to formula I;NH2—S2—X1—S1—COOH  (formula I);wherein
X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide,S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and— denotes a peptide bond,

wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.

主权项

1. A fusion polypeptide comprising a polypeptide according to formula I
NH2—S2—X1—S1—COOH  (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, and wherein X1 is inserted in place of the insert-in-flap-domain (IF-domain) of the second polypeptide.