发明名称 |
COMPOSITION COMPRISING TWO ANTIBODIES ENGINEERED TO HAVE REDUCED AND INCREASED EFFECTOR FUNCTION |
摘要 |
The present invention provides combinations of (a) an immunoconjugate comprising a first antibody engineered to have reduced effector function and an effector moiety, and (b) a second antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them. |
申请公布号 |
HK1210789(A1) |
申请公布日期 |
2016.05.06 |
申请号 |
HK20150111524 |
申请日期 |
2015.11.23 |
申请人 |
ROCHE GLYCART AG |
发明人 |
GERDES, CHRISTIAN;KLEIN, CHRISTIAN;NICOLINI, VALERIA G.;UMANA, PABLO |
分类号 |
C07K;A61K;A61P |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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