发明名称 |
New Telescoping Synthesis Of 2- Methoxymethyl-P-Phenylenediamine |
摘要 |
A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-hydroxymethylaniline. |
申请公布号 |
US2016122286(A1) |
申请公布日期 |
2016.05.05 |
申请号 |
US201514926163 |
申请日期 |
2015.10.29 |
申请人 |
The Procter & Gamble Company |
发明人 |
ABEL Heike Gertrud;OSAN Armin;GARRETT Garry Steven;GARDLIK John Michael;MURPHY Bryan Patrick;SPECKBACHER Markus;WEBER Ingo Reinhold |
分类号 |
C07C213/06;C07C213/02;C07C245/10;C07C245/24;C07C245/20 |
主分类号 |
C07C213/06 |
代理机构 |
|
代理人 |
|
主权项 |
1. A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine (I), a cosmetically acceptable salt thereof, or mixture thereof comprising the steps of:
a) synthesizing the intermediate 2-(hydroxymethyl)-4-{3-[2-(hydroxymethyl)phenyl]triaz-1-en-1-yl}aniline (IV) via diazotation using 2-hydroxymethylaniline (II) to obtain the intermediate of formula (III) followed by diazo coupling between the intermediate of formula (III) and 2-hydroxymethylaniline (II): b) synthesizing the intermediate 2-(hydroxymethyl)-4-{(E)-[2-(hydroxymethyl)phenyl]diazenyl}aniline of formula (V) via rearrangement of the intermediate 2-(hydroxymethyl)-4-{3-[2-(hydroxymethyl)phenyl]triaz-1-en-1-yl}aniline (IV) obtained in step a): c) synthesizing 2-hydroxymethyl-p-phenylenediamine (VI) and 2-hydroxymethylaniline (II) via hydrogenation of the compound of formula (V): d) synthesizing 2-methoxymethyl-p-phenylenediamine (I) via acid catalysed etherification of the compound of formula (VI): |
地址 |
Cincinnati OH US |