发明名称 |
ALPHA AMINO ACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASES |
摘要 |
Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator. |
申请公布号 |
CA2836827(C) |
申请公布日期 |
2016.05.03 |
申请号 |
CA20062836827 |
申请日期 |
2006.05.04 |
申请人 |
CHROMA THERAPEUTICS LTD. |
发明人 |
DAVIDSON, ALAN HORNSBY;DRUMMOND, ALAN HASTINGS;NEEDHAM, LINDSEY ANN |
分类号 |
A61K47/48;C07K17/02;C12N5/07;C12Q1/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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