Anti-malarial compositions

摘要

This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.

主权项

1. An isolated antibody which:
(a) comprises:
(1) an immunoglobulin heavy chain variable region, comprising a first heavy chain complementarity determining region (CDRH) comprising the amino acid sequence SEQ ID NO:1; a second CDRH comprising the amino acid sequence SEQ ID NO:2; and a third CDRH comprising the amino acid sequence SEQ ID NO:3; and(2) an immunoglobulin light chain variable region comprising a first light chain complementarity determining region (CDRL) comprising the amino acid sequence SEQ ID NO:4; a second CDRL comprising the amino acid sequence SEQ ID NO:5; and a third CDRL comprising the amino acid sequence SEQ ID NO:6; or (b) comprises the complementarity determining regions of the immunoglobulin heavy and light chains of the antibody deposited under Accession No. MRA-1242.