CMP-ACETYLNEURAMINIC ACID HYDROXYLASE TARGETING VECTOR, TRANSGENIC ANIMAL FOR XENOTRANSPLANTATION INTRODUCED WITH THE VECTOR, AND METHOD OF MANUFACTURING THE SAME

摘要

There is provided a CMP-acetylneuraminic acid hydroxylase targeting vector, a transgenic animal for xenotransplantation introduced with the vector, and a method of manufacturing the same. The targeting vector and the cell line for transformation prepared by the present invention can be used for the efficient production of cloned pigs for xenotransplantation by the complex regulation of the expression of the genes involved in the immunological rejection responses.

主权项

1. A CMP-acetylneuraminic acid hydroxylase targeting vector comprising CMP-acetylneuraminic acid hydroxylase 5′ arm, PGKneopolyA, and CMP-acetylneuraminic acid hydroxylase 3′ arm in sequential order.