| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: group of inventions refers to drugs, particularly to novel method of treating breast cancer, providing for parenteral administering therapeutically effective amount of (R)-4,11-dihydroxy-3-[(pyrrolidine-3-ylamino)methyl]-1H-naphto[2,3-f]indole-5,10-dione of formula I or its pharmaceutically acceptable salt.Further, group of inventions also refers to antitumour pharmaceutical compositions for parenteral use of compounds of formula I, containing compound I, pharmacologically acceptable carrier and one or more excipients specified in co-solvents, solubilisers, filling agents, emulsifiers, preservatives, antioxidants, buffer compounds, substances for maintaining isotonicity.EFFECT: said compositions provide effective use of the compound I, because well soluble in water pharmacologically acceptable mediums, have high stability during storage in the form of lyophilisate, and in form of aqueous solutions.5 cl, 6 tbl, 4 ex |
