APOE PEPTIDE DIMERS AND USES THEREOF

摘要

The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention comprise at least two ApoE mimetic domains and can comprise one or more protein transduction domains. Methods of treating various conditions, such as cancer, inflammatory conditions, and neurodegenerative diseases, by administering the pharmaceutical compositions of the invention are also disclosed.

主权项

1. A peptide dimer comprising a first ApoE peptide and a second ApoE peptide, wherein each of said first and second ApoE peptides is no more than 20 amino acids in length and comprises a sequence selected from the group consisting of LRVRLAS(Aib)LKRLRK(Nitro-Arg)LL (SEQ ID NO. 4), AS(Aib)LRKL(Aib)KRLL (SEQ ID NO: 5), CLRVRLASHLRKLRKRLL (SEQ ID NO: 15), CAS(Aib)LRKL(Aib)KRLL (SEQ ID NO: 16), CLRVRLAS(Aib)LKRLRK(Nitro-Arg)LL (SEQ ID NO: 17), and CLRVRLAS(Aib)LRKLR(K-Ac)RLL (SEQ ID NO: 18), and LRVRLAS(Aib)LRKLR(K-Ac)RLL (SEQ ID NO: 35), and wherein the first and second ApoE peptides are covalently linked through amino acid residues in each of the peptides via a bismaleimide linker.