发明名称 |
Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
摘要 |
A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses human immunoglobulin light chain variable domains derived from a limited repertoire of human immunoglobulin light chain variable gene segments that comprise histidine modifications in their germline sequence. Methods of making non-human animals that express antibodies comprising histidine residues encoded by histidine codons introduced into immunoglobulin light chain nucleotide sequences are provided. |
申请公布号 |
AU2014323527(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
AU20140323527 |
申请日期 |
2014.09.18 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MCWHIRTER, JOHN;MACDONALD, LYNN;MURPHY, ANDREW J. |
分类号 |
A01K67/027;C07K16/00;C07K16/28 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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