Methods for acquiring and evaluating mass spectra in fourier transform mass spectrometers

摘要

The invention provides a method for acquiring a mass spectrum with a Fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by Coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain.

主权项

1. A method for acquiring a mass spectrum of analyte ions with a Fourier transform mass spectrometer, comprising the steps of:
providing the analyte ions and at least one reporter ion in a measuring cell wherein the analyte ions and the at least one reporter ion oscillate at mass specific frequencies in the measuring cell and interact by coulomb forces; recording a time domain signal of the reporter ion motion; and determining a mass signal of the analyte ions from a sideband signal of the at least one reporter ion in the frequency domain or from the instantaneous frequency of the at least one reporter ion in the time domain, wherein the interaction between the analyte ions and the reporter ion periodically modulates the reporter ion motion in time and generates the sideband signal in addition to the fundamental signal of the reporter ion in the frequency domain.