发明名称 |
NANOCOMPLEXES FOR DELIVERY OF SAPORIN |
摘要 |
A nanocomplex, of particle size 50 nm to 1000 nm, containing saporin and a lipid-like compound, in which saporin binds to the lipid-like compound via non-covalent interaction or covalent bonding. The lipid-like compound has a hydrophilic moiety, a hydrophobic moiety, and a linker joining the hydrophilic moiety and the hydrophobic moiety. The hydrophilic moiety is optionally charged and the hydrophobic moiety has 8 to 24 carbon atoms. Also disclosed is a pharmaceutical composition containing such a nanocomplex and a pharmaceutically acceptable carrier. The nanocomplex is useful in treating diseases, such as cancer. |
申请公布号 |
US2016082126(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
US201414890510 |
申请日期 |
2014.05.13 |
申请人 |
TUFTS UNIVERSITY |
发明人 |
Xu Qiaobing;Wang Ming |
分类号 |
A61K47/48;A61K38/16 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
|
主权项 |
1. A nanocomplex comprising saporin and a lipid-like compound, wherein the nanocomplex has a particle size of 50 nm to 1000 nm; the saporin binds to the lipid-like compound via non-covalent interaction or covalent bonding; and the lipid-like compound has a hydrophilic moiety, a hydrophobic moiety, and a linker joining the hydrophilic moiety and the hydrophobic moiety, the hydrophilic moiety being optionally charged and the hydrophobic moiety having 8 to 24 carbon atoms. |
地址 |
Medford MA US |