发明名称 |
Multicomponent crystalline system comprising deferasirox and isonicotinamide and a process for the preparation thereof |
摘要 |
The present invention refers to a multicomponent crystalline system (co-crystal) comprising a compound of formula (1) (4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid; INN: Deferasirox) formula (1) and a compound of formula (2) (Isonicotinamide; pyridine-4-carboxamide) formula (2), as well as to a process for obtaining the same.; |
申请公布号 |
US9290452(B2) |
申请公布日期 |
2016.03.22 |
申请号 |
US201314415875 |
申请日期 |
2013.08.05 |
申请人 |
BASF SE |
发明人 |
Hafner Andreas;Blatter Fritz;Roedel Eva;Szelagiewicz Martin;Chiodo Tiziana;Hintermann Tobias;Salvador Beate;Vossen Marcus |
分类号 |
C07D213/81;C07D249/08 |
主分类号 |
C07D213/81 |
代理机构 |
Oblon, McClelland, Maier & Neustadt, L.L.P |
代理人 |
Oblon, McClelland, Maier & Neustadt, L.L.P |
主权项 |
1. A multicomponent crystalline system, comprising a compound of formula 1, which is 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid: and a compound of formula 2, which is isonicotinamide; pyridine-4-carboxamide: |
地址 |
Ludwigshafen DE |