| 主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
R1 is —R, halogen, —OR, —SR, —N(R′)2, —CN, —NO2, —C(O)R, —CO2R, —C(O)N(R′)2, —C(O)SR, —C(O)C(O)R, —C(O)CH2C(O)R, —C(S)N(R′)2, —C(S)OR, —S(O)R, —SO2R, —SO2N(R′)2, —N(R′)C(O)R, —N(R′)C(O)N(R′)2, —N(R′)SO2R, —N(R′)SO2N(R′)2, —N(R′)N(R′)2, —N(R′)C(═N(R′))N(R′)2, —C═NN(R′)2, —C═NOR, —C(═N(R′))N(R′)2, —OC(O)R, or —OC(O)N(R′)2; each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, an 8-10 membered bicyclic saturated, partially unsaturated or aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R′ is independently —R, —C(O)R, —CO2R, or two R′ on the same nitrogen are taken together with their intervening atoms to form a 4-7 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; Ring A is R2 and R3 are independently —R, halogen, —OR, —SR, —N(R′)2, —CN, —NO2, —C(O)R, —CO2R, —C(O)N(R′)2, —C(O)SR, —C(O)C(O)R, —C(O)CH2C(O)R, —C(S)N(R′)2, —C(S)OR, —S(O)R, —SO2R, —SO2N(R′)2, —N(R′)C(O)R, —N(R′)C(O)N(R′)2, —N(R′)SO2R, —N(R′)SO2N(R′)2, —N(R′)N(R′)2, —N(R′)C(═N(R′))N(R′)2, —C═NN(R′)2, —C═NOR, —C(═N(R′))N(R′)2, —OC(O)R, or —OC(O)N(R′)2; or:
R2 and R3 are taken together with their intervening atoms to form an optionally substituted 5-7 membered partially unsaturated or aromatic fused ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; R2′ is —R, —OR, —SR, —N(R′)2, —C(O)R, —CO2R, —C(O)N(R′)2, —C(O)SR, —C(O)C(O)R, —C(O)CH2C(O)R, —C(S)N(R′)2, —C(S)OR, —S(O)R, —SO2R, —SO2N(R′)2, —N(R′)C(O)R, —N(R′)C(O)N(R′)2, —N(R′)SO2R, —N(R′)SO2N(R′)2, —N(R′)N(R′)2, —N(R′)C(═N(R′))N(R′)2, —C═NN(R′)2, —C═NOR, —C(═N(R′))N(R′)2, —OC(O)R, or —OC(O)N(R′)2; or:
R2′ and R3 are taken together with their intervening atoms to form an optionally substituted 5-7 membered partially unsaturated or aromatic fused ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; X is —N(R4)—, —O—, or —S—; R4 is —R, —C(O)R, —CO2R, or —S(O)2R; or:
R4 and R3 are taken together with their intervening atoms to form an optionally substituted 5-7 membered saturated, partially unsaturated, or aromatic fused ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; R5 is R, —C(O)R, —CO2R, —C(O)N(R′)2, —C(O)C(O)R, or —C(O)CH2C(O)R; or:
R5 and R2 are taken together with their intervening atoms to form an optionally substituted 5-7 membered partially unsaturated or aromatic fused ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and R6 is —R, halogen, —OR, —SR, —N(R′)2, —CN, —NO2, —C(O)R, —CO2R, —C(O)N(R′)2, —C(O)SR, —C(O)C(O)R, —C(O)CH2C(O)R, —C(S)N(R′)2, —C(S)OR, —S(O)R, —SO2R, —SO2N(R′)2, —N(R′)C(O)R, —N(R′)C(O)N(R′)2, —N(R′)SO2R, —N(R′)SO2N(R′)2, —N(R′)N(R′)2, —N(R′)C(═N(R′))N(R′)2, —C═NN(R′)2, —C═NOR, —C(═N(R′))N(R′)2, —OC(O)R, or —OC(O)N(R′)2; or:
R6 and R3 are taken together with their intervening atoms to form an optionally substituted 5-7 membered partially unsaturated or aromatic fused ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;provided that the compound is other than any one of the following:and provided the compound is not a compound of formula (II):wherein:
R1 is 3-(methylamino)propyl, when R2 is ethoxycarbonyl, and R3 is H; R1 is H, when R2 is H, and R3 is 2,3-dihydro-1,4-benzodioxin-6-yl; R1 is methoxy, when R2 is H, and R3 is 4-chlorophenyl; R1 is hydroxy, when R2 is H, and R3 is 4-chlorophenyl; R1 is H, when R2 is ethyl, ethoxycarbonylmethyl, 2-hydroxypropyl, 2-(acyloxy)propyl, 2-(acyloxy)ethyl, 2-(2-(N-benzyloxycarbonylamino)propanoyloxy)propyl, 2-chloropropyl, 1-(ethoxycarbonyl)ethyl, ethoxycarbonylmethyl, 1-(carboxy)ethyl, 1-(1-(methoxycarbonylethyl)ethoxycarbonyl)ethyl, 2-hydroxy-1-methylethyl, 2-hydroxyethyl, or 4-(trifluoromethylthio)benzyl, and R3 is methyl; R1 is H, when R2 is H, and R3 is phenyl, tetrahydropyran-4-ylmethyl, chloromethyl, methoxycarbonyl, ethoxycarbonylmethyl, benzyl, or 1-(2-fluorophenyl)cyclopropyl; R1 is H, when R2 is H, 4-benzyloxyphenyl, 3,4-dihydro-6,7-dimethyl-3-oxo-2-quinoxalinyl, or indol-3-yl, 3-pyrazolyl, ethoxycarbonyl, cyano, 3,4-dihydro-3-oxo-2-quinoxalinyl, or carboxy, and R3 is H; R1 is 3-aminopiperidino, when R2 is H, and R3 is trifluoromethyl; R1 is H, methyl, phenyl, N-(4-fluorophenyl)amino, N-phenylamino, N-benzylamino, N-(3,5-dimethoxyphenyl)amino, N-(3-methoxyphenyl)amino, N-(4-methoxyphenyl)amino, N-(3,4-dimethoxyphenyl)amino, N-(4-methylphenyl)amino N-(2-methoxyphenyl)amino, 4,5,6,7-tetrahydro-1H-indol-2-yl, N-(4-fluorophenyl)amino or N-(4-propylphenyl)amino, when R2 is H, and R3 is methyl; R1 is phenylamino, when R2 is H, and R3 is isopropyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is H, and R3 is phenyl, 2-fluorophenyl, 2-chlorophenyl, or chloromethyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is chloro, and R3 is methyl; R1 is methyl, N-(4-morpholinophenyl)amino, N-(3-methoxy-4-(2-morpholinoethoxy)phenyl)amino, N-(3,5-dimethoxyphenyl)amino, or N-(4-propylphenyl)amino, when R2 is H, and R3 is ethyl; R1 is N-(3-methoxy-5-(2-morpholinoethoxy)phenyl)amino, N-(3,5-dimethoxyphenyl)amino, phenylamino, N-(4-bromophenyl)amino, or N-(4-morpholinophenyl)amino, when R2 is H, and R3 is cyclopropyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is H, and R3 is isopropyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is methyl, and R3 is methyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is fluoro, and R3 is methyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is H, and R3 is methoxymethyl; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is H, and R3 is methoxycarbonylmethyl; R1 is H, methyl or N-(3,5-dimethoxyphenyl)amino, when R2 is H, and R3 is propyl; R1 is H, methyl or N-(3,5-dimethoxyphenyl)amino, when R2 is benzyl, and R3 is methyl; R1 is H or methyl, when R2 is benzyl, and R3 is H; R1 is N-(3,5-dimethoxyphenyl)amino, when R2 is H, and R3 is phenyl, 2-pyridyl, or N,N-dimethylaminomethyl; R1 is H, when R2 is 2-hydroxyethyl, 2-chloroethyl, 2-(acyloxy)ethyl, and R3 is ethoxycarbonyl; R1 is H, when R2 is 2-hydroxyethyl, and R3 is hydroxy; R1 is H, when R2 is 2-(acyloxy)ethyl, and R3 is benzyloxymethyl; R1 is 2-pyrrolyl, when R2 is H, and R3 is H; R1 is N-(4-ethoxyphenyl)amino, when R2 is 3,4-dihydro-6,7-dimethyl-3-oxo-2-quinoxalinyl, and R3 is H; R1 is H, when R2 is 2-(acyloxy)ethyl, and R3 is methoxymethyl; R1 is H, when R2 is cyano, and R3 is phenyl or 4-chlorophenyl; R1 is methyl, when R2 is 3,4-dihydro-3-oxo-2-quinoxalinyl, and R3 is H; R1 is H, when R2 and R3 taken together form a fused benzo ring; R1 is H, when R2 is 3-methoxybenzyl, and R3 is propyl; R1 is methyl, when R2 is H, ethyl, ethoxycarbonylmethyl, or 3-chlorobenzyl, and R3 is methyl; R1 is pyrrolidino, when R2 is H, and R3 is 3-chlorobenzyl, 5-(propyl)isoxazol-3-yl, or 4-nitrophenyl; R1 is morpholino, when R2 is H, and R3 is tetrahydropyran-2-yl; R1 is pyrrolidino, when R2 is benzoylamino, and R3 is H; R1 is N-(4-methoxyphenyl)amino, when R2 is H, and R3 is 4-nitrophenyl; R1 is H, when R2 is 2-(2,4-dichlorobenzoyloxy)ethyl, 2-(3-methylbenzoyloxy)ethyl, 2-(acetoxy)ethyl or 2-(cyclohexylcarbonyloxy)ethyl, and R3 is methyl; R1 is methyl, when R2 and R3 taken together form a fused cyclopentyl ring; R1 is H, when R2 and R3 taken together form a fused cyclohexyl ring; R1 is methyl, when R2 is H, and R3 is ethoxycarbonylmethyl; R1 is phenyl, when R2 is H, and R3 is methyl or amino; R1 is H, when R2 is chloro, and R3 is methyl; R1 is methyl, R2 is H, and R3 is phenyl; R1 is methyl, R2 is 2-hydroxyethyl, and R3 is methyl; or R1 is methylthio, R2 is H, and R3 is phenyl; andprovided that the compound is other than any one of the following: |
