Chimeric Natriuretic Peptide Compositions and Methods of Preparation

摘要

Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.

主权项

1. A composition comprising:
a peptide selected from the group consisting of CD-NP (Seq. ID. No. 1), CU-NP (Seq.ID No. 4), B-CDNP (Seq. ID. No. 8), CDNP-B (Seq. ID. No. 9), and variants of CD-NP, CU-NP, B-CDNP, and CDNP-B having one to five conservative amino acid substitutions, wherein the peptide is present in a concentration from about 0.05 mg/mL to about 20 mg/mL; about 0.15% to about 0.315% meta-cresol; water; and, one or more buffers selected from the group consisting of tris(hydoxymethyl)aminomethane and a phosphate buffer.