| 发明名称 |
METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) |
| 摘要 |
The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) with fatty acid derivatives; and new methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid derivative. The present invention is also directed to fatty acid bioative derivatives and their use in the treatment of metabolic diseases. |
| 申请公布号 |
EP2854787(A4) |
申请公布日期 |
2016.02.24 |
| 申请号 |
EP20130794508 |
申请日期 |
2013.05.24 |
| 申请人 |
CATABASIS PHARMACEUTICALS, INC. |
发明人 |
MILNE, JILL C.;JIROUSEK, MICHAEL R.;VU, CHI B. |
| 分类号 |
A61K31/12;A61K31/44;A61P3/00;A61P3/10;C07C235/20;C07D207/14;C07D213/56;C07D213/61;C07D213/82;C07D401/06;C07D401/12;C07D405/12 |
主分类号 |
A61K31/12 |
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