DNA photolithography with cinnamate crosslinkers

摘要

The present invention relates generally to cinnamate crosslinkers. Specifically, the present invention relates to gels, biochips, and functionalized surfaces useful as probes, in assays, in gels, and for drug delivery, and methods of making the same using a newly-discovered crosslinking configuration.

主权项

1. A composition comprising:
a first substrate having a first surface nucleic acid strand comprising a first cinnamate functional group and forming a first sticky end, a second substrate having a second surface nucleic acid strand comprising a second cinnamate functional group and forming a second sticky end, the first sticky end and the second sticky end substantially complementary and hybridizable with each other; wherein the first substrate and the second substrate are covalently bonded via the first cinnamate functional group and the second cinnamate functional group.