| 发明名称 |
METHODS FOR MODULATING CHEMOTHERAPEUTIC CYTOTOXICITY |
| 摘要 |
Disclosed herein are methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a chemotherapeutic agent. Example disclosed methods reduce cardiotoxicity of a chemotherapeutic agent. Also disclosed are methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a chemotherapeutic agent. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the chemotherapeutic agent. |
| 申请公布号 |
US2016045532(A1) |
申请公布日期 |
2016.02.18 |
| 申请号 |
US201414775428 |
申请日期 |
2014.03.13 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV |
发明人 |
Roberts David D.;Soto Pantoja David R. |
| 分类号 |
A61K31/713;A61K31/513;A61K45/06;A61K31/704 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells, comprising administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and one or more chemotherapeutic agents, wherein the agent that inhibits CD47 signaling is administered to the subject before, during, or after administration of the one or more chemotherapeutic agents. |
| 地址 |
Bethesda MD US |
