| 发明名称 |
Conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases |
| 摘要 |
Conjugates of a polymer having attached thereto an angiogenesis targeting moiety and a therapeutically active agent such as an anti-cancer agent or anti-angiogenesis agent, and processes of preparing same are disclosed.;Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of angiogenesis-related medical conditions such as cancer and cancer metastases are also disclosed. |
| 申请公布号 |
US9259482(B2) |
申请公布日期 |
2016.02.16 |
| 申请号 |
US201314082224 |
申请日期 |
2013.11.18 |
| 申请人 |
Ramot at Tel-Aviv University Ltd.;Fundacion de la Comunidad Valenciana Centro de Investigacion Principe Felipe |
发明人 |
Satchi-Fainaro Ronit;Vicent Docon Maria Jesus |
| 分类号 |
A61K31/74;A61K47/48;A61K31/336;A61K31/337;G01N33/68;A61K49/00 |
主分类号 |
A61K31/74 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A conjugate having the structure: wherein: x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; and w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9. |
| 地址 |
Tel-Aviv IL |
