TREATMENT OF INSULIN RESISTANCE AND DIABETES

摘要

Disclosed are methods, compositions, and cells useful for increasing insulin sensitivity, as well as lack of insulin production in a host in need thereof. One aspect of the invention discloses methods of increasing skeletal muscle perfusion through administration of cells capable of directly and/or indirectly stimulatory of angiogenesis and/or vascular responsiveness. Another aspect provides means of increasing sensitivity to insulin through administration of a cell composition capable of integrating into host insulin responsive tissue and upregulating responsiveness either through mobilization of host cells capable of responding to insulin, mobilization of host cells capable of endowing insulin responsiveness on other host cells, exogenously administered cells taking the role of insulin responsiveness, or exogenously administered cells endowing insulin responsiveness on other host cells. Another aspect comprises modifying said host to allow for concurrent insulin sensitization and upregulated production of insulin.

主权项

1. A method of ameliorating the effects of insulin resistance in a mammal comprising: identifying a mammal suffering from insulin resistance; and administering to said mammal a mesenchymal stem cell population in an amount sufficient to increase insulin sensitivity in the mammal and wherein the mesenchymal stem cell population expresses the markers CD90 and CD105 while substantially lacking CD45 and CD14 expression.